Tirzepatide

Tirzepatide (LY3298176) is a synthetic 39-amino-acid peptide that activates two receptors: GIP and GLP-1. Supplied as a lyophilised powder in a 30 mg or 40 mg vial for laboratory research.

Structure

• Peptide backbone. A GIP-based 39-residue sequence with α-aminoisobutyric acid (Aib) at two positions, which increases resistance to enzymatic degradation.
• Lipid chain. A C20 diacid attached to a lysine side chain through a linker. It binds albumin, so the compound persists longer in research models.
• C-terminus – amidated.

Research areas

• GIP and GLP-1 receptor binding and activation studies in cell models.
• Biased signalling, cAMP and β-arrestin pathways compared with single-receptor agonists.
• Peptide stability, pharmacokinetics and analytical method development (HPLC, MS).

Packaging

A sealed glass vial with an aluminium crimp cap. Every vial carries a batch number and expiry date.

For laboratory research only. Not for human or animal use.